Follow-up study in people underway — ScienceDaily

In a new study, green tea reduced obesity and many inflammatory biomarkers associated with poor health.

The diet of mice fed 2% green tea extract is much better than the diet without it. This finding prompted the potential benefits of upcoming research on green tea for people at high risk for diabetes and heart disease.

The benefits seen in the new study published in the Journal of Nutritional Biochemistry appear to stem from improved intestinal health, including lower permeability of the more beneficial microbes and intestinal wall in the mouse gut. . – People often call it a "leakage" condition.

"This study provides evidence that green tea can promote intestinal bacterial growth and can significantly reduce the risk of obesity," said Richard Bruno, a professor of human nutrition at the study's lead author. At Ohio State University.

Negative changes in the gut microbiome have previously been associated with obesity, and green tea has been shown to promote healthy bacteria. The Ohio State team wants to discuss whether there is a debate about green tea to prevent obesity, inflammation, and other factors associated with metabolic health, and Bruno, a member of the Ohio Center for Agricultural Research and Development.

"So far, the results of the study on obesity management are a true hybrid package. Some seem to support green tea to lose weight, but many other studies have shown no effect, probably because of the complexity of the diet relative to many lifestyle factors. The goal is to figure out how it prevents weight gain," he said. “This will lead to better health advice.”

Green tea has a long history in Asian countries and is increasingly accepted by the West, in part because of its potential health benefits. Catechin, an anti-inflammatory polyphenol found in green tea, is associated with anti-cancer activity and a reduced risk of heart and liver disease.

Bruno and his colleagues suspect that green tea can prevent obesity and prevent intestinal inflammation based on previous studies, so they designed an experiment to examine the effects of green tea on male mice designed for normal and high-fat diets leading to obesity. (Female mice are resistant to diet-induced obesity and insulin resistance, which are precursors to diabetes and are therefore not included.)

For eight weeks, half of the animals ate a high-fat diet, which led to obesity and half of the regular diet. In these groups, the half-tea green tea extract was mixed with its food.

The researchers then measured the weight of body and adipose tissue, insulin resistance and other factors, including:

  • intestinal permeability, or the way the intestinal leaks
  • Endotoxin translocation, or movement of intestinal bacterial-derived components to the bloodstream, causing inflammation and insulin resistance
  • Adipose tissue and intestinal inflammation
  • Ingredients of intestinal microbes, known to have Helping various health factors

Mice fed a high-fat diet supplemented with green tea gained about 20% of their body weight, and insulin resistance was lower than that of mice fed the same diet without tea.

These mice also have less inflammation in adipose tissue and intestines. In addition, green tea seems to prevent endotoxin (toxic bactericidal components) from flowing into the bloodstream from the intestines.

In addition, the researchers also found evidence that these mice are stronger – less "leak". Leaky gut is a problem for humans, leading to widespread low-grade inflammation and has been involved in many health problems.

The researchers also found that green tea appears to contribute to the healthy microbial community in the gut of mice fed a high-fat diet. Feeding mice supplemented with a normal or low-fat diet of green tea also has benefits, including a reduction in weight gain and a decrease in endotoxin levels and markers of intestinal leakage, but these are relatively mild compared to mice fed a high-fat diet. .

The consumption of green tea in the experiment is equivalent to about 10 cups of green tea per person, Bruno said.

"It looks like a lot of tea, but it is not very unusual in some parts of the world," he said.

Bruno is currently conducting a human study that will examine the effects of green tea on the leaky bowel in patients with metabolic syndrome – a disease that makes people susceptible to type 2 diabetes and heart disease.

Now, he said, it is still too early to infer the results of animal research to people. He also warned that – if human benefits prove to be correct – green tea supplements will not be a significant substitute for a day's drink, because the body metabolizes the catechins in tea.

"It takes a little bit of food in a day's food – as the mice did in this study – might be better," Bruno said.

He said he hopes that future research will determine whether drinking green tea is a good strategy for those who want to reduce their chances of reducing obesity.

"Two-thirds of American adults are overweight or obese. We know that it is not enough to tell people to eat less and eat more. It is very important to establish a supplementary health promotion method that can prevent obesity and related problems," Bruno said. .

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