Majority of oral medications available to consumers contain ingredients that can affect sensitive individuals — ScienceDaily
A new study led by Brigham and Women's Hospital and the Massachusetts Institute of Technology's research team found that the vast majority of the most commonly prescribed drugs in the United States contain at least one component that causes adverse effects. reaction. These ingredients, called inactive ingredients, improve oral taste, shelf life, absorption and other properties, but the authors found that more than 90% of all oral medications tested contained at least one ingredient that caused allergies or allergies. Gastrointestinal symptoms in sensitive individuals. These ingredients include lactose, peanut oil, gluten and chemical dyes. The team's findings are published in Science Translational Medicine .
"When you are a clinician, the last thing you have to do is to prescribe a drug that can cause adverse reactions or allergic reactions in patients," the corresponding author C. Giovanni Traverso, MB, BChir, PhD, a gastroenterologist at the Department of Gastroenterology at Brigham and the Department of Mechanical Engineering at the Massachusetts Institute of Technology. “The project was inspired by a real event where patients with celiac disease prescribed medicine and they added gluten from the formula of the pill from the pharmacy. We want to understand the problem and delve into the world. Inactive ingredients across thousands of drugs across the country."
Traverso and biochemical data scientist Daniel Reker, Ph.D., physician Steven Blum, MD, Brigham Pharmacy Executive Director John Fanikos, MBA, RPH, etc., analyzed data on inactive ingredients in 42,052 oral drugs. Contains more than 354,597 inactive ingredients. Inactive ingredients are defined as substances that are added to a pill formulation but are not intended or intended to have a direct biological or therapeutic effect. Although these ingredients have been tested for safety at the population level, disaggregated case reports indicate that inactive ingredients may adversely affect individuals with allergies or intolerance.
"The real attraction of this data set is its complexity," Reker said. “There are hundreds of different versions of pills or capsules that use the same combination of different inactive ingredients to provide the same drug. This highlights the complexity of the choice of inactive ingredients, but it also shows that there is an untapped opportunity today for specific choices for people with The most appropriate drug version for patients with abnormal sensitivity."
The team found that a total of 38 inactive ingredients were described in the literature as causing allergic symptoms after oral exposure. The authors report that 92.8% of the drugs they analyzed contained at least one of these inactive ingredients. Specifically, they report:
- About 45% of drugs contain lactose;
- About 33% of drugs contain food dyes;
- and only 0.08% The drug contains lactose containing peanut oil, and for some drugs – such as progesterone – there are few alternatives that do not contain this inactive ingredient.
The authors point out that inactive ingredients can cause adverse reactions through allergies (a histamine-related reaction that can cause urticaria, dyspnea and/or allergic reactions) or intolerance, which is difficult to absorb. Substances can cause gastrointestinal symptoms. It is unclear what the amount of ingredients needed to trigger a reaction in a sensitive individual – for example, the lactose content of a drug may be too low to cause a response in many patients, except for severe lactose intolerance or those taking many lactose-containing Drug person.
"Although we call these ingredients inactive, but in many cases they are not. Although the dose may be low, we don't know what the individual's response threshold is in most cases. ," Traverso said. . “This prompted us to consider the role of precision care and regulation and legislation in labeling drugs that contain ingredients that may cause adverse reactions.”
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