Simple urine test allows for rapid diagnosis of preeclampsia — ScienceDaily

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Researchers at Ohio State University School of Medicine, Ohio State University's Wexner Medical Center, and National Children's Hospital found that simple urine testing can quickly detect one of the world's deadliest pregnancy-related diseases. Has a major impact on global health.

To reduce the disease and death of pregnant women and their unborn children, maternal-feminal medicine and perinatal physicians have designed a rapid tool to identify pre-eclampsia using affordable non-invasive clinical "red dye paper." Tested and tested in a clinical study at the Wexner Medical Center in Ohio. The results are published in Lancet's E-Clinical Medicine .

"This is the first clinical study using an immediate, paper-based Congo Red Dot (CRD) diagnostic test that has proven superior in establishing or eliminating the diagnosis of pre-eclampsia," Dr. Cara said. Rood, first author of the Cox's Medical Center in Ohio and Ph.D. “Our findings will have a huge impact on the health of women and children.”

Currently, pre-eclampsia is identified by high blood pressure and certain proteins in the urine. This disease is the leading cause of doctors' decision to have children too early and causes approximately 18% of maternal deaths in the United States


"Pre-eclampsia affects up to 8% of pregnancies. The challenge is that it is a progressive disease, not everyone's progress at the same time," said Rood, an assistant professor of maternal-fetal medicine at Ohio State University. Medical school. “Some women may have been ill for a few weeks before symptoms appear, and other women may develop to dangerous levels within a few days.”

In this study, the researchers recruited 346 pregnant women who were receiving hypertension and a possible assessment of pre-eclampsia. They used the CRD urine test to provide results at the bedside within 3 minutes. The trained clinical research nurse analyzed the results before the patient's doctor made the final diagnosis. The results of the CRD test were not shared with the patient care team.

The clinical diagnosis of 89 pregnant women is pre-eclampsia. Of these, 79% were due to pre-eclampsia, and the average delivery age was 33 weeks of gestation. The team found that the CRD test was superior to other biochemical tests with an accuracy rate of 86%.

These findings confirm that the CRD test is a simple "sample in/out" clinical tool that can diagnose pre-eclampsia very accurately and quickly, Rood said.

"Pre-eclampsia is often described as "mystery" because it is difficult to diagnose," said Dr. K. Craig Kent, Dean of the School of Medicine. “I am proud of our dedicated researchers who are looking for a simple, non-invasive test method to help diagnose this condition and keep the health of pregnant women and their babies.”

Pre-eclampsia can cause eclampsia if undetected, which is one of the top five causes of maternal and infant diseases – including epilepsy and coma – and 13% of maternal deaths worldwide. Pregnant women may be induced and early childbirth in an unborn child, even if only pre-eclampsia is suspected. Preterm birth is also a problem because it increases the risk of neonatal learning disabilities, cerebral palsy and blindness.

Rood said that in addition to the use of this test by clinicians during prenatal appointments, she also considers this a simple tool for pregnant women in underdeveloped countries that lack resources.

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